Моноклональные мышиные антитела к MGMT
MGMT (O-methylguanine-DNA methyltransferase) Ab-1
Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.
Спецификация
Информация для заказа
| Область использования: | Производство: | Thermo Fisher Scientific |
| Метод: | Иммуногистохимия |
| Объем: | 0.5ml |
| Кат. номер: | MS-470-P1 |
| Цена (с НДС 20%): | по запросу | В корзину  |
 Наименование: Моноклональные мышиные антитела к MGMT / MGMT (O-methylguanine-DNA methyltransferase) Ab-1.
Примечание: Клон: MT 3.1 |
