HoxA10 (E-11)

• HoxA10 Antibody (E-11) is a mouse monoclonal IgG₁ (kappa light chain) provided at 200 µg/ml
• specific for an epitope mapping between amino acids 39-74 near the N-terminus of HoxA10 of human origin
• HoxA10 Antibody (E-11) is recommended for detection of HoxA10 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
• TransCruz reagent for ChIP application (sc-271428 X, 200 µg/0.1 ml)
• HoxA10 Antibody (E-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
• also available conjugated to Alexa Fluor^® 488, Alexa Fluor^® 546, Alexa Fluor^® 594 or Alexa Fluor^® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
• also available conjugated to Alexa Fluor^® 680 or Alexa Fluor^® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR^®Odyssey^®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
• blocking peptide, sc-271428 P
• See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.

The Hox homeobox genes encode proteins that are transcriptional regulators with an established role in embryonic development. The HoxA10 gene is related to the Abdominal B (AbdB) homeobox subfamily of genes and is expressed in both the developing genitourinary tract and in the adult uterus. HoxA10 expression increases during the midsecretory phase of the menstrual cycle, which corresponds with increased levels of circulating progesterone, as evidenced by Northern blot analysis. Furthermore, HoxA10 expression in-creases in a concentration-dependent manner with progesterone stimulation in cultured endometrial cells and is blocked by the progesterone receptor antagonist RU486. In addition, HoxA10 is differentially expressed in the myometrium throughout the menstrual cycle, both in vivo and in vitro, with decreased expression coinciding with increased progesterone levels. In contrast with a control group, female patients with documented endometriosis do not exhibit a mid-luteal increase in uterine Hox gene expression, which may contribute to the pathology of the disease.

 

 

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Информация для заказа

Область использования: Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-271428
Цена (с НДС 20%):	по запросу	В корзину
Наименование: HoxA10 (E-11). Примечание: For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, ELISA, UNSPSC: 12352203, datasheet