SMPD2 Antibody
SMPD2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody
Application WB, FC
Primary Accession O60906
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Clone Names RB17400
Calculated MW 47646
Additional Information
Gene ID 6610
Other Names Sphingomyelin phosphodiesterase 2, Lyso-platelet-activating
factor-phospholipase C, Lyso-PAF-PLC, Neutral sphingomyelinase, N-SMase,
nSMase, SMPD2
Target/Specificity This SMPD2 antibody is generated from rabbits immunized with a KLH
conjugated synthetic peptide between 9-35 amino acids from the N-terminal
region of human SMPD2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation
followed by dialysis against PBS.
Storage Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store
at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions SMPD2 Antibody (N-term) is for research use only and not for use in
diagnostic or therapeutic procedures.
Protein Information
Name SMPD2 ( HGNC:11121)
Function Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide
and phosphocholine (PubMed:10608884). Also hydrolyzes
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor)
2 of 3
in vivo (PubMed:10608884). Also acts on 1-acyl-2-lyso-snglycero-
3-phosphocholine (lyso-PC) and sphingosylphosphocholine
(PubMed:10608884, PubMed:14741383).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:O70572}; Multi-pass membrane
protein
Background
SMPD2 converts sphingomyelin to ceramide and hydrolyzes 1-acyl-2-lyso-sn-glycero-3-phosphocholine
(lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological
substrate seems to be Lyso-PAF.
Информация для заказа
| Область использования: | Производство: | Puda Scientific |
| Метод: | |
| Объем: | 100 мкг |
| Кат. номер: | PDA-2922a |
| Цена (с НДС 20%): | по запросу | В корзину  |
Наименование: SMPD2 Antibody.
Примечание: |
