SMPD3 Antibody
SMPD3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
Product Information
Application WB
Primary Accession Q9NY59
Other Accession O35049, Q9JJY3, NP_061137.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Clone Names RB39878
Calculated MW 71081
Additional Information
Gene ID 55512
Other Names Sphingomyelin phosphodiesterase 3, Neutral sphingomyelinase 2, nSMase-2, nSMase2, Neutral
sphingomyelinase II, SMPD3
Target/Specificity This SMPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic
peptide between 137-165 amino acids from the N-terminal region of human SMPD3.
Dilution WB~~1：1000
Format Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is
prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in
small aliquots to prevent freeze-thaw cycles.
Precautions SMPD3 Antibody (N-term) is for research use only and not for use in diagnostic or
therapeutic procedures.
Protein Information
Name SMPD3 ( HGNC:14240)
Function Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine.
Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest,
and is capable of regulating these 2 cellular events independently. Also hydrolyzes
sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in
confluent cells. Probably acts as a regulator of postnatal development and participates in
bone and dentin mineralization (PubMed:10823942, PubMed:14741383,
PubMed:15051724). Binds to anionic phospholipids (APLs) such as
phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and
subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes
(By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the
NF-kappa-B activation under inflammatory conditions (By similarity).
2 of 2
Cellular Location Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor.
Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic
neurosecretory neurons (PubMed:10823942). Localizes to plasma membrane in confluent
contact- inhaibited cells (PubMed:15051724)
Tissue Location Predominantly expressed in brain.
Background
SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular
functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes
sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of
postnatal development and participates in bone and dentin mineralization.
Информация для заказа
| Область использования: | Производство: | Puda Scientific |
| Метод: | |
| Объем: | 100 мкл |
| Кат. номер: | PDA-18071a |
| Цена (с НДС 20%): | по запросу | В корзину  |
Наименование: SMPD3 Antibody .
Примечание: |
