Козьи поликлональные антитела к PUMA α (N-20)PUMAα (N-20)
- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of PUMAα of human origin
- recommended for detection of PUMAα of mouse, rat and human origin by WB, IF and ELISA
- blocking peptide, sc-20534 P
PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMAå, ∫, © and ∂. Both PUMAå and PUMA∫ contain a BH3 domain, while PUMA© and PUMA∂ lack this domain. The BH3 domain is essential for binding of PUMAå and PUMA∫ to Bcl-2 or Bcl-xL. PUMA is an initiator of ©-radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region. Информация для заказа| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 200 мкг/мл | | Кат. номер: | sc-20534 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Козьи поликлональные антитела к PUMA α (N-20) / PUMAα (N-20).
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: human,
Applications: WB, IF, ELISA,
UNSPSC: 12352203,
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