Антитела mouse anti- Human Cardiac Troponin I monoclonal Antibody
mouse anti- Human Cardiac Troponin I monoclonal Antibody
Species:
Immunogen: Recombinant Human Cardiac Troponin I protein
Raised in:mouse
Species Reactivity: Hu, Ms, Rat, Cat, Cow, Dog, Fsh, Goat, Mk, Pig, Rb
Tested Applications: ELISA(Recommended pairs for the detection of Double-antibody sandwich ELISA), WB, and other possible application
Isotype: IgG2b
Purity: >95% by Caprylic Acid Ammonium Sulfate Precipitation purified
Strorage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 .
Conjugate: Non-conjugated
Relevance: Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium..
Clonality: monoclonal.
Form: liquid.
Strorage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles..
References: [1] Apple FS.Tissue specificity of cardiac troponin I,cardiac troponin T and creatine Kinase-MB[J].Clin Chim Acta,1999,284:151-159 [2] Stein PD, Janjua M, Matta F, Pathak PK, Jaweesh F, Alrifai A, Chughtai HL. Prognosis based on creatine kinase isoenzyme MB, cardiac troponin I, and right ventricular size in stable patients with acute pulmonary embolism. Am J Cardiol. 2011,107(5):774-7. [3] Goel S, Beith JM. Troponin I as a predictor for trastuzumab-related cardiotoxicity: current data do not provide mechanistic insights or allow for incorporation into clinical practice. J Clin Oncol. 2011,29(7):e175-6. [4] Xue Y, Clopton P, Peacock WF, Maisel AS. Serial changes in high-sensitive troponin I predict outcome in patients with decompensated heart failure. Eur J Heart Fail. 2011,13(1):37-42. [5] Paparella D, Scrascia G, Paramythiotis A, Guida P, Magari V, Malvindi PG, Favale S, de Luca Tupputi Schinosa L. Preoperative cardiac troponin I to assess midterm risks of coronary bypass grafting operations in patients with recent myocardial infarction. Ann Thorac Surg. 2010 ,89(3):696-702. [6] John J, Woodward DB, Wang Y, Yan SB, Fisher D, Kinasewitz GT, Heiselman D. Troponin-I as a prognosticator of mortality in severe sepsis patients. J Crit Care. 2010,25(2):270-5. [7] Tsutamoto T, Kawahara C, Nishiyama K, Yamaji M, Fujii M, Yamamoto T, Horie M. Prognostic role of highly sensitive cardiac troponin I in patients with systolic heart failure. Am Heart J. 2010 ,159(1):63-7. [8] van Geene Y, van Swieten HA, Noyez L. Cardiac troponin I levels after cardiac surgery as predictor for in-hospital mortality. Interact Cardiovasc Thorac Surg. 2010,10(3):413-6. [9] Zahid M, Good CB, Singla I, Sonel AF. Clinical significance of borderline elevated troponin I levels across different assays in patients with suspected acute coronary syndrome. Am J Cardiol. 2009,104(2):164-8. [10] Alonso Martinez JL, Anniccherico Sanchez FJ, Urbieta Echezarreta MA, Garcia Sanchotena JL, Ezcurra Ibañez M, Lasa Inchausti B. Clinical usefulness of troponin I in acute pulmonary embolism. Med Clin (Barc). 2009,133(6):201-5. [11] Waxman DA. Troponin I is an independent predictor of all-cause mortality in hospitalized patients with congestive heart failure. Am Heart J. 2007 Nov;154(5) [12] Ather S, Hira RS, Shenoy M, Fatemi O, Deswal A, Aguilar D, Ramasubbu K, Bolos M, Chan W, Bozkurt B. Recurrent low-level Troponin I elevation is a worse prognostic indicator than occasional injury pattern in patients hospitalized with heart failure. Int J Cardiol. 2011, 24. [13]Oshima K, Kunimoto F, Takahashi T, Mohara J, Takeyoshi I, Hinohara H, Okawa M, Saito S. Postoperative cardiac troponin I (cTnI) level and its prognostic value for patients undergoing mitral valve surgery. Int Heart J. 2010,51(3):166-9. [14] Napan S, Kashinath RC, Kadri S, Orig MN, Khadra S. Prognostic significance of preprocedural troponin-I in patients with non-ST elevation acute coronary syndromes undergoing percutaneous coronary intervention. Coron Artery Dis. 2010,21(5):261-5. [15] Bonaca M, Scirica B, Sabatine M, Dalby A, Spinar J, Murphy SA, Jarolim P, Braunwald E, Morrow DA. Prospective evaluation of the prognostic implications of improved assay performance with a sensitive assay for cardiac troponin I. J Am Coll Cardiol. 2010,55(19):2118-24. [16] Tsutamoto T, Kawahara C, Nishiyama K, Yamaji M, Fujii M, Yamamoto T, Horie M. Prognostic role of highly sensitive cardiac troponin I in patients with systolic heart failure. Am Heart J. 2010,159(1):63-7. [17] Fruchter O, Yigla M. Cardiac troponin-I predicts long-term mortality in chronic obstructive pulmonary disease. COPD. 2009,6(3):155-61. .
Информация для заказа
| Область использования: | Производство: | Cusabio |
| Метод: | |
| Объем: | 100 мкг |
| Кат. номер: | CSB-MA079362A0m |
| Цена (с НДС 20%): | по запросу | В корзину  |
Наименование: Антитела mouse anti- Human Cardiac Troponin I monoclonal Antibody / mouse anti- Human Cardiac Troponin I monoclonal Antibody.
Примечание: дополнительная информация (на английском языке). |
