Антитела Mouse anti- Human Retinol-binding protein 4 monoclonal antibody

Mouse anti- Human Retinol-binding protein 4 monoclonal antibody

Species:
Immunogen: Recombinant Human Retinol-binding protein 4 protein
Raised in:mouse
Species Reactivity: Human
Tested Applications: ELISA, WB, and other possible application
Isotype: IgG1
Purity: >95% by Caprylic Acid Ammonium Sulfate Precipitation purified
Strorage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 .
Conjugate: Non-conjugated
Relevance: Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity..
Clonality: monoclonal.
Form: liquid.
Strorage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
References: [1] Zhou F, Huang Q, Dai X, Yin J, Wu J, Zhou H, Gong Z, Liu Z. Impact of retinol binding protein 4 polymorphism on rosiglitazone response in Chinese Type 2 diabetic patients. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Oct;36(10):949-57. [2] Mellati AA, Sharifi F, Sajadinejad M, Sohrabi D, Mazloomzadeh S. The relationship between retinol-binding protein 4 levels, insulin resistance, androgen hormones and polycystic ovary syndrome. Scand J Clin Lab Invest. 2011 Oct 24. [3] Lorkova L, Pospisilova J, Lacheta J, Leahomschi S, Zivny J, Cibula D, Zivny J, Petrak J. Decreased concentrations of retinol-binding protein 4 in sera of epithelial ovarian cancer patients: A potential biomarker identified by proteomics. Oncol Rep. 2011 Oct 21. doi: 10.3892/or.2011.1513. [4] Shaker O, El-Shehaby A, Zakaria A, Mostafa N, Talaat S, Katsiki N, Mikhailidis DP. Plasma visfatin and retinol binding protein-4 levels in patients with type 2 diabetes mellitus and their relationship to adiposity and fatty liver. Clin Biochem. 2011 Dec;44(17-18):1457-63. Epub 2011 Sep 12. [5] Chen PY, Huang MC, Chiu CC, Liu HC, Lu ML, Chen CH. Association of plasma retinol-binding protein-4, adiponectin, and high molecular weight adiponectin with metabolic adversities in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Dec 1;35(8):1927-32. Epub 2011 Aug 5. [6] Chu CH, Lam HC, Lee JK, Lu CC, Sun CC, Cheng HJ, Wang MC, Chuang MJ. Elevated serum retinol-binding protein 4 concentrations are associated with chronic kidney disease but not with the higher carotid intima-media thickness in type 2 diabetic subjects. Endocr J. 2011 Oct 29;58(10):841-7. Epub 2011 Aug 4. [7] Ahn KJ, Choi EA, Kim J, Lee JH, Lee KH, Bang D, Cho SB. Increased retinol-binding protein (RBP) 4 and anti-RBP4 antibody in alopecia areata. Br J Dermatol. 2011 Oct;165(4):837-44. doi: 10.1111/j.1365-2133.2011.10482.x. [8] Chan TF, Tsai YC, Wu CH, Lee CH, Wang SH, Su JH. The positive correlation between cord serum retinol-binding protein 4 concentrations and fetal growth. Gynecol Obstet Invest. 2011;72(2):98-102. Epub 2011 Jun 16. [9] Rhie YJ, Choi BM, Eun SH, Son CS, Park SH, Lee KH. Association of serum retinol binding protein 4 with adiposity and pubertal development in Korean children and adolescents. J Korean Med Sci. 2011 Jun;26(6):797-802. Epub 2011 May 18. [10] Park CS, Ihm SH, Park HJ, Shin WS, Kim PJ, Chang K, Kim HY, Youn HJ, Chung WS, Seung KB, Kim JH. Relationship between plasma adiponectin, retinol-binding protein 4 and uric Acid in hypertensive patients with metabolic syndrome. Korean Circ J. 2011 Apr;41(4):198-202. [11] Christou GA, Tellis CC, Elisaf MS, Tselepis AD, Kiortsis DN. The Changes in Plasma Retinol-Binding Protein 4 Levels are Associated With Those of the Apolipoprotein B-Containing Lipoproteins During Dietary and Drug Treatment. Angiology. 2011 May 20. .

Информация для заказа

Область использования: Прочие антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкг
	Кат. номер:	CSB-MA074271A0m
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Антитела Mouse anti- Human Retinol-binding protein 4 monoclonal antibody / Mouse anti- Human Retinol-binding protein 4 monoclonal antibody. Примечание: дополнительная информация (на английском языке).