Антитела Mouse anti-Bovine TNF alpha monoclonal antibodyMouse anti-Bovine TNF alpha monoclonal antibodyСпецификация| Объем | 100 мкг | | Code NO# | 2E1A5 | | Синонимы | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2 | | Тип антител | Monoclonal Antibody | | Видовая специфичность | Bovine | | Uniport ID | Q06599 | | Иммуноген | Recombinant Bovine TNF alpha protein | | Источник | mouse | | Видовая специфичность 1 | Bovine | | Применение | ELISA | | Примечание | Tumor necrosis factor alpha (TNFalpha,also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNFalpha is produced by a wide variety of immune and epithelial cell types. Bovine TNFalpha consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 178 aa extracellular domain (ECD). Within the ECD, bovine TNFalpha shares 64%-83% sequence identity with canine, cotton rat, equine, feline, human, mouse, porcine, rat, and rhesus TNFalpha.The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness. Cleavage of membrane bound TNFalpha by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNFalpha. TNFalpha trimers bind the ubiquitous TNF RI and the hematopoietic cell restricted TNF RII, both of which are also expressed as homotrimers. TNFalpha regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNFalpha is a key cytokine in several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism. | | Изотип | IgG2b | | Метод очистки | >95%,Protein G purified | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Области исследований | Others | | Станица на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкг | | Кат. номер: | CSB-MA084771A0m | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Антитела Mouse anti-Bovine TNF alpha monoclonal antibody / Mouse anti-Bovine TNF alpha monoclonal antibody.
Примечание: дополнительная информация (на английском языке). |
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