Антитела Mouse anti- human Myoglobin monoclonal antibody
Mouse anti- human Myoglobin monoclonal antibody
Species:
Immunogen: Recombinant Human Myoglobin protein
Raised in:mouse
Species Reactivity: Human
Tested Applications: ELISA, WB, IHC
Isotype: IgG2a
Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
Strorage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
Conjugate: Non-conjugated
Relevance: Myoglobin is a small heme containing protein (153 amino acid residues, molecular weight (w/o heme) 17053 Da and theoretical pI=7.29) responsible for the oxygen deposition in muscle tissues. Only one form of myoglobin is expressed in cardiac and skeletal muscles. Myoglobin is known as a marker of myocardial damage and it has been used for more than three decades. Nowadays it still is very commonly used in clinical practice as an early marker of AMI. It appears in patient's blood 1 to 3 hours after onset of the symptoms, reaching peak level within 8 to 12 hours. Myoglobin is not so cardiac specific as cTnI or cTnT. Because of high myoglobin concentration in skeletal muscle tissue, even minor skeletal muscle injury results in the significant increase of myoglobin concentration in blood. Thus myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis..
Clonality: monoclonal.
Form: liquid.
Strorage: Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze..
References: [1] Karabay O, Tuna N, Ogutlu A, Gozdas HT.High ferritin and myoglobin level in legionella pneumonia: a case report and review of literature. Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):381-3. [2] Liu M, Hou M, Liu LP, Zhang CX, Zhao CY, Ma CJ, Zhong SN, Song Y.The value of determination of serum myoglobin in estimation of degree of illness and prognosis of patients with sepsis in Xining area. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Feb;23(2):85-7. [3] Orak M, Ustundağ M, Guloğlu C, Gökhan S, Alyan O.Relation between serum Pro-Brain natriuretic peptide, myoglobin, CK levels and morbidity and mortality in high voltage electrical injuries. Intern Med. 2010;49(22):2439-43. Epub 2010 Nov 15. [4] Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, Ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA.Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression? J Biol Chem. 2011 Sep 19. [5] Hendgen-Cotta UB, Flögel U, Kelm M, Rassaf T.Unmasking the Janus face of myoglobin in health and disease. J Exp Biol. 2010 Aug 15;213(Pt 16):2734-40. [6] Liu Y.Radioimmunoassay and immunohistochemical study of myoglobin in neuromuscular diseases. Zhonghua Yi Xue Za Zhi. 1992 Mar;72(3):144-6, 190. [7] Lovece S, Kagen LJ.Sensitive rapid detection of myoglobin in serum of patients with myopathy by immunoturbidimetric assay. J Rheumatol. 1993 Aug;20(8):1331-4. [8] Nicholson LV.Serum myoglobin in muscular dystrophy and carrier detection. J Neurol Sci. 1981 Sep;51(3):411-26. [9] Mula-Abed WA, Al-Sinani SS, Al-Hashmi HS.Serum myoglobin in patients with thyroid dysfunction. Sultan Qaboos Univ Med J. 2009 Apr;9(1):37-41. Epub 2009 Mar 16. [10] Goksu E, Oktay C, Kilicaslan I, Kartal M.Seizure or syncope: the diagnostic value of serum creatine kinase and myoglobin levels. Eur J Emerg Med. 2009 Apr;16(2):84-6. [11]Kagen LJ. Myoglobinemia and myoglobinuria in patients with myositis. Arthritis Rheum. 1971 Jul–Aug;14(4):457–464. [12] Kasaoka S, Todani M, Kaneko T, Kawamura Y, Oda Y, Tsuruta R, Maekawa T.Peak value of blood myoglobin predicts acute renal failure induced by rhabdomyolysis.J Crit Care. 2010 Dec;25(4):601-4. [13] Rodriguez-Capote K, Balion CM, Hill SA, Cleve R, Yang L, El Sharif A.Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review.Clin Chem. 2009 Dec;55(12):2190-7. Epub 2009 Oct 1. Review. [14] Moselhy SS, Demerdash SH.Serum free L-carnitine in association with myoglobin as a diagnostic marker of acute myocardial infarction.Clin Biochem. 2009 Jan;42(1-2):78-82. Epub 2008 Sep 30. [15] Kontos MC, Garg R, Anderson FP, Roberts CS, Ornato JP, Tatum JL, Jesse RL.Ability of myoglobin to predict mortality in patients admitted for exclusion of myocardial infarction.Am J Emerg Med. 2007 Oct;25(8):873-9. [16] Loun B, Astles R, Copeland KR, Sedor FA.Adaptation of a quantitative immunoassay for urine myoglobin. Predictor in detecting renal dysfunction.Am J Clin Pathol. 1996 Apr;105(4):479-86. [17] Laios ID, Caruk R, Wu AH.Myoglobin clearance as an early indicator for rhabdomyolysis-induced acute renal failure.Ann Clin Lab Sci. 1995 Mar-Apr;25(2):179-84..
Alias: .
Информация для заказа
| Область использования: | Производство: | Cusabio |
| Метод: | |
| Объем: | 100 мкг |
| Кат. номер: | CSB-MA079101A0m |
| Цена (с НДС 20%): | по запросу | В корзину  |
Наименование: Антитела Mouse anti- human Myoglobin monoclonal antibody / Mouse anti- human Myoglobin monoclonal antibody.
Примечание: дополнительная информация (на английском языке). |
