Антитела Goat anti-human Retinol-binding protein 4 polyclonal Antibody

Goat anti-human Retinol-binding protein 4 polyclonal Antibody

Immunogen: Recombinant human RBP4 protein
Raised in: Goat
Species Reactivity: Human
Tested applications: ELISA,WB,LETIA, IHC
Application notes:
Relevance: Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.
Clonality: Polyclonal
Isotype: IgG
Purity: >95% by Caprylic Acid Ammonium Sulfate Precipitation
Conjugate: Non-conjugated
Stroage Buffer: 0.01M PB, PH 7.4
Form: Liquid
Stroage: Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
References: [1] Zhou F, Huang Q, Dai X, Yin J, Wu J, Zhou H, Gong Z, Liu Z. Impact of retinol binding protein 4 polymorphism on rosiglitazone response in Chinese Type 2 diabetic patients. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Oct;36(10):949-57. [2] Mellati AA, Sharifi F, Sajadinejad M, Sohrabi D, Mazloomzadeh S. The relationship between retinol-binding protein 4 levels, insulin resistance, androgen hormones and polycystic ovary syndrome. Scand J Clin Lab Invest. 2011 Oct 24. [3] Lorkova L, Pospisilova J, Lacheta J, Leahomschi S, Zivny J, Cibula D, Zivny J, Petrak J. Decreased concentrations of retinol-binding protein 4 in sera of epithelial ovarian cancer patients: A potential biomarker identified by proteomics. Oncol Rep. 2011 Oct 21. doi: 10.3892/or.2011.1513. [4] Shaker O, El-Shehaby A, Zakaria A, Mostafa N, Talaat S, Katsiki N, Mikhailidis DP. Plasma visfatin and retinol binding protein-4 levels in patients with type 2 diabetes mellitus and their relationship to adiposity and fatty liver. Clin Biochem. 2011 Dec;44(17-18):1457-63. Epub 2011 Sep 12. [5] Chen PY, Huang MC, Chiu CC, Liu HC, Lu ML, Chen CH. Association of plasma retinol-binding protein-4, adiponectin, and high molecular weight adiponectin with metabolic adversities in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Dec 1;35(8):1927-32. Epub 2011 Aug 5. [6] Chu CH, Lam HC, Lee JK, Lu CC, Sun CC, Cheng HJ, Wang MC, Chuang MJ. Elevated serum retinol-binding protein 4 concentrations are associated with chronic kidney disease but not with the higher carotid intima-media thickness in type 2 diabetic subjects. Endocr J. 2011 Oct 29;58(10):841-7. Epub 2011 Aug 4. [7] Ahn KJ, Choi EA, Kim J, Lee JH, Lee KH, Bang D, Cho SB. Increased retinol-binding protein (RBP) 4 and anti-RBP4 antibody in alopecia areata. Br J Dermatol. 2011 Oct;165(4):837-44. doi: 10.1111/j.1365-2133.2011.10482.x. [8] Chan TF, Tsai YC, Wu CH, Lee CH, Wang SH, Su JH. The positive correlation between cord serum retinol-binding protein 4 concentrations and fetal growth. Gynecol Obstet Invest. 2011;72(2):98-102. Epub 2011 Jun 16. [9] Rhie YJ, Choi BM, Eun SH, Son CS, Park SH, Lee KH. Association of serum retinol binding protein 4 with adiposity and pubertal development in Korean children and adolescents. J Korean Med Sci. 2011 Jun;26(6):797-802. Epub 2011 May 18. [10] Park CS, Ihm SH, Park HJ, Shin WS, Kim PJ, Chang K, Kim HY, Youn HJ, Chung WS, Seung KB, Kim JH. Relationship between plasma adiponectin, retinol-binding protein 4 and uric Acid in hypertensive patients with metabolic syndrome. Korean Circ J. 2011 Apr;41(4):198-202. [11] Christou GA, Tellis CC, Elisaf MS, Tselepis AD, Kiortsis DN. The Changes in Plasma Retinol-Binding Protein 4 Levels are Associated With Those of the Apolipoprotein B-Containing Lipoproteins During Dietary and Drug Treatment. Angiology. 2011 May 20. [12] Yildizhan R, Ilhan GA, Yildizhan B, Kolusari A, Adali E, Bugdayci . Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome. Fertil Steril. 2011 Jul;96(1):246-50. Epub 2011 May 19. [13] Mohapatra J, Sharma M, Acharya A, Pandya G, Chatterjee A, Balaraman R, Jain MR. Retinol-binding protein 4 : a possible role in cardiovascular complications. Br J Pharmacol. 2011 Dec;164(8):1939-48. doi: 10.1111/j.1476-5381.2011.01492.x. [14] Chayanupatkul M, Honsawek S, Chongsrisawat V, Vimolket L, Poovorawan Y. Serum retinol binding protein 4 and clinical outcome in postoperative biliary atresia. Hepatol Int. 2011 Mar 6. [15] Mostafaie N, Sebesta C, Zehetmayer S, Jungwirth S, Huber KR, Hinterberger M, Leitha T, Hofman J, Hejtman M, Schrattbauer K, Krugluger W, Tragl KH, Fischer P. Circulating retinol-binding protein 4 and metabolic syndrome in the elderly. Wien Med Wochenschr. 2011 Apr 4. [16] Romanowska A, Lebensztejn DM, Skiba E, Tarasow E, Kaczmarski M. Retinol binding protein-4 as a serum biomarker of intrahepatic lipid content in obese children--preliminary report.. Acta Biochim Pol. 2011;58(1):35-8. [17] Friebe D, Neef M, Erbs S, Dittrich K, Kratzsch J, Kovacs P, Bluher M, Kiess W, Körner A. Retinol binding protein 4 (RBP4) is primarily associated with adipose tissue mass in children. Int J Pediatr Obes. 2011 Jun;6(2-2):e345-52. Epub 2010 Oct 15. [18] Yeste D, Vendrell J, Tomasini R, Gallart LL, Clemente M, Simon I, Albisu M, Gussinye M, Audi L, Carrascosa A. Retinol-binding protein 4 levels in obese children and adolescents with glucose intolerance. Horm Res Paediatr. 2010;73(5):335-40. Epub 2010 Apr 14.
Images:

Western blot

Predicted band size :22 kDa
Observed band size : 22-23 kDa

 

Alias : Plasma retinol-binding protein, PRBP, RBP, RBP4, PRO2222.

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкг
	Кат. номер:	CSB-PA07057A0G
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Антитела Goat anti-human Retinol-binding protein 4 polyclonal Antibody / Goat anti-human Retinol-binding protein 4 polyclonal Antibody. Примечание: дополнительная информация (на английском языке).