Антитела mouse anti-Human MFGE8 monoclonal Antibodymouse anti-Human MFGE8 monoclonal AntibodyСпецификация| Объем | 100 мкг | | Code NO# | 2B2D10 | | Синонимы | Lactadherin,Breast epithelial antigen,BA46 ,HMFG,MFGM Milk fat globule-EGF factor 8 | | Тип антител | Monoclonal Antibody | | Видовая специфичность | Human | | Uniport ID | Q08431 | | Иммуноген | Recombinant Human MFGE8 protein | | Источник | Mouse | | Видовая специфичность 1 | Human | | Перекрестная реактивность | specific for MFGE8 native and denatured forms | | Применение | ELISA,IHC,Recommended dilution:IHC:1:50-1:500 | | Примечание | Human MFGE8(milk fat globule-EGF factor 8,also lactadherin, breast epithelial antigen BA46, and medin) is a 46 kDa, secreted, monomeric glycoprotein that is associated with the human milk fat globule (HMFG) membrane.It is expressed by mammary epithelial cell surfaces, artery media, and in several carcinomas .Human MGFE8 is synthesized as a 387 amino acid (aa) precursor that contains a 23 aa signal sequence and a 364 aa mature region. The mature molecule contains four Nlinked glycosylation sites, an aminoterminal EGF like domain, plus C1 and C2 Iglike domains which are related to discoidin I and homologous to those of human coagulation factors V and VIII . Within the EGF like domain is an ArgGlyAsp(RGD) sequence, which is strategically placed in a hairpin loop between two antiparallel beta strands. In this way, the EGFlike domain serves as a scaffold for the RGD sequence, which is proposed to promote cell adhesion by binding cellsurface integrin receptors, such as ??v??3. Human MFGE8 shares 59%, 58%, 56%, and 52% aa sequence identity with porcine, bovine, rat, and mouse MFGE8,respectively. Functionally, MFGE8 in milk is reported to block rotavirus infection . MFGE8 expression by macrophages promotes the phagocytosis of apoptotic thymocytes by forming a bridge between phosphatidylserine on apoptotic cells, and ??v??3 integrin on phagocytes . The MFGE8 expression by macrophages controls the accumulation of apoptotic membrane fragments in atherosclerotic plaques and substantially limits lesion development . | | Изотип | IgG2b | | Метод очистки | >95%,Protein G purified | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Области исследований | Cardiovascular,Developmental biology,Microbiology | | Станица на сайте производителя | ссылка | Immunohistochemical of paraffin-embedded human Colon cancer tissues using CSB-MA079741A0m at dilution of 1:200
 | Immunohistochemical of paraffin-embedded human breast cancer tissue using CSB-MA079741A0m at dilution of 1:200
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкг | | Кат. номер: | CSB-MA079741A0m | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Антитела mouse anti-Human MFGE8 monoclonal Antibody / mouse anti-Human MFGE8 monoclonal Antibody.
Примечание: дополнительная информация (на английском языке). |
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