Антитела Rabbit anti-Human IgM polyclonal Antibody,HRP conjugated

Rabbit anti-Human IgM polyclonal Antibody,HRP conjugated

Immunogen: IgM purified from human serum
Raised in: Rabbit
Species Reactivity: Human
Tested applications: ELISA, WB, IHC
Application notes:
Relevance: IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.
Clonality: Polyclonal
Isotype: IgM
Purity: CA-AS
Conjugate: HRP
Stroage Buffer: PBS
Form: Liquid
Stroage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
References:
Images:
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Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкг
	Кат. номер:	CSB-PA00140F1Rb
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Антитела Rabbit anti-Human IgM polyclonal Antibody,HRP conjugated / Rabbit anti-Human IgM polyclonal Antibody,HRP conjugated. Примечание: дополнительная информация (на английском языке).