Объем | 100 мкг |
Синонимы | Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products), AGER, RAGE |
Клональность | Polyclonal Antibody |
Организм | Human |
uniprot | Q15109 |
Иммуноген | Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA) |
Источник | Rabbit |
Видовая специфичность | Human, Mouse |
Применение | ELISA, IHC, IF, Recommended dilution: IHC:1:50-1:200, IF:1:50-1:500 |
Примечание | Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. |
Клональность1 | Polyclonal |
Изотип | IgG |
Коньюгат | Non-conjugated |
Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Форма | Liquid |
Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Метод очистки | >95%, Protein G purified |
Абревеатура | Advanced glycosylation end product-specific receptor protein |
Области исследований | Neuroscience, Cardiovascular |
Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemistry of paraffin-embedded Mouse liver tissue using CSB-PA14209A0Rb at dilution of 1:50
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Immunofluorescence staining of MCF-7 cells with CSB-PA14209A0Rb at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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