Антитела Rabbit anti-human Advanced glycosylation end product-specific receptor polyclonal Antibody;Biotin conjugatedRabbit anti-human Advanced glycosylation end product-specific receptor polyclonal Antibody;Biotin conjugatedСпецификация| Объем | 100 мкг | | Синонимы | Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products), AGER, RAGE | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q15109 | | Иммуноген | Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Biotin | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Advanced glycosylation end product-specific receptor protein | | Области исследований | Neuroscience, Cardiovascular | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкг | | Кат. номер: | CSB-PA14209D0Rb | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Антитела Rabbit anti-human Advanced glycosylation end product-specific receptor polyclonal Antibody;Biotin conjugated / Rabbit anti-human Advanced glycosylation end product-specific receptor polyclonal Antibody;Biotin conjugated.
Примечание: дополнительная информация (на английском языке). |
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