Антитела Rabbit anti-human Ubiquitin-like protein ISG15 polyclonal Antibody;Biotin conjugated

Rabbit anti-human Ubiquitin-like protein ISG15 polyclonal Antibody;Biotin conjugated

Спецификация

Объем	100 мкг
Синонимы	Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP), ISG15, G1P2 UCRP
Клональность	Polyclonal Antibody
Организм	Human
uniprot	P05161
Иммуноген	Recombinant Human Ubiquitin-like protein ISG15 protein (2-157AA)
Источник	Rabbit
Видовая специфичность	Human
Применение	ELISA
Примечание	Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Biotin
Буффер	Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Форма	Liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	>95%, Protein G purified
Области исследований	Epigenetics and Nuclear Signaling, Cell biology
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Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкг
	Кат. номер:	CSB-PA09744D0Rb
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Антитела Rabbit anti-human Ubiquitin-like protein ISG15 polyclonal Antibody;Biotin conjugated / Rabbit anti-human Ubiquitin-like protein ISG15 polyclonal Antibody;Biotin conjugated. Примечание: дополнительная информация (на английском языке).