Антитела Rabbit anti-human Mucin-1 polyclonal Antibody;Biotin conjugated

Rabbit anti-human Mucin-1 polyclonal Antibody;Biotin conjugated

Immunogen:
Raised in: Rabbit
Species Reactivity: Human
Tested applications: ELISA, WB, IHC
Application notes:
Relevance: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. Ref.26 Ref.37 Ref.40 Ref.45 Ref.46 Ref.49 Ref.52 Ref.53 Ref.56.The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Clonality: Polyclonal
Isotype: IgG
Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
Conjugate: Biotin conjugated
Stroage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form: Liquid
Stroage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
References: [1] "Cloning and sequencing of a human pancreatic tumor mucin cDNA."Lan M.S., Batra S.K., Qi W.-N., Metzgar R.S., Hollingsworth M.A.J. Biol. Chem. 265:15294-15299(1990) [2] "Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini."Ligtenberg M.J.L., Vos H.L., Gennissen A.M.C., Hilkens J.J. Biol. Chem. 265:5573-5578(1990) [3] "Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin."Gendler S.J., Lancaster C.A., Taylor-Papadimitriou J., Duhig T., Peat N., Burchell J., Pemberton L., Lalani E.-N., Wilson D.J. Biol. Chem. 265:15286-15293(1990)
Images:
Alias : PUM,MUC1,Breast carcinoma-associated antigen DF3 Carcinoma-associated mucin,Episialin,H23AG,Krebs von den Lungen-6,KL-6,PEMT,Peanut-reactive urinary mucin,PUM,Polymorphic epithelial mucin,PEM,Tumor-associated epithelial membrane antigen,EMA,Tumor-associated mucin,CD_antigen=CD227.

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкг
	Кат. номер:	CSB-PA11317D0Rb
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Антитела Rabbit anti-human Mucin-1 polyclonal Antibody;Biotin conjugated / Rabbit anti-human Mucin-1 polyclonal Antibody;Biotin conjugated. Примечание: дополнительная информация (на английском языке).