Mouse anti- Human Epidermal growth factor receptor monoclonal antibody

Product Type: Monoclonal antibodies
Uniprot ID: P00533
 Immunogen: Recombinant Human Epidermal growth factor receptor
 Raised in: mouse
 Species Reactivity: Human,Other species are not tested.Please decide the specificity by homology
 Spectificity: specific for human Epidermal growth factor receptor denatured forms
 Tested Applications: ELISA, WB, and other possible application
 Relevance: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
 Clonality: monoclonal
 Isotype: IgG1
 Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
 Conjugate: Non-conjugated
 Stroage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Form: liquid
 Stroage: Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
 References: [1]. Lee S, de Boer WB, Fermoyle S, Platten M, Kumarasinghe MP. Human epidermal growth factor receptor 2 testing in gastric carcinoma: issues related to heterogeneity in biopsies and resections.Histopathology. 2011 Nov;59(5):832-40. doi: 10.1111/j.1365-2559.2011.04017.x. [2]. Watzka SB, Posch F, Hochmair M, Setinek U, Köstler WJ, Muller MR.Resistance to EGFR targeting therapies in lung cancer. Minerva Chir. 2011 Oct;66(5):483-94. [3]. Nunes-Xavier CE, Elson A, Pulido R. EGFR-mediated positive feedback of PTP{epsilon} on ERK1/2 and AKT pathways is required for survival of human breast cancer cells.J Biol Chem. 2011 Nov 23. [4]. Stella GM, Luisetti M, Inghilleri S, Cemmi F, Scabini R, Zorzetto M, Pozzi E.Targeting EGFR in non-small-cell lung cancer: Lessons, experiences, strategies.Respir Med. 2011 Nov 19.
Alias : Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1.

Информация для заказа

Область использования: Моноклональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкг
	Кат. номер:	CSB-MA102771A0m
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Mouse anti- Human Epidermal growth factor receptor monoclonal antibody. Примечание: дополнительная информация (на английском языке).