Rabbit Anti Human ErbB2 PolyClonal AntibodyСпецификация| Объем | 100 мкл (100 мкг) | | Синонимы | ErbB2, CD340,HER-2,HER-2/neu,HER2,NEU,NGL,TKR1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P04626 | | Иммуноген | A synthetic peptide of human ERBB2 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100 | | Примечание | The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy. Phosphorylation of the kinase domain residue Tyr877 of ErbB2 (homologous to Tyr416 of pp60c-Src) may be involved in regulating ErbB2 biological activity. The major autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222, phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Affinity purification | | Области исследований | Cancer,Tags & Cell Markers,Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts of HeLa cell line, using ERBB2 antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкл (100 мкг) | | Кат. номер: | CSB-PA007763KA01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Rabbit Anti Human ErbB2 PolyClonal Antibody.
Примечание: дополнительная информация (на английском языке). |
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