Rabbit Anti Human PLCG2 PolyClonal AntibodyСпецификация| Объем | 100 мкл (100 мкг) | | Синонимы | PLCG2,APLAID,FCAS3 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P16885 | | Иммуноген | Recombinant protein of human PLCG2 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200 | | Примечание | Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLCbeta, PLCgamma, PLCδ and PLCε. The PLCbeta subfamily includes four members, PLCbeta1-4. All four members of the subfamily are activated by alpha- or beta-gamma-subunits of the heterotrimeric G-proteins.Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA or PKC inhibits PLCbeta3 activity. Ser537 of PLCbeta3 is phosphorylated by CaMKII, and this phosphorylation may contribute to the basal activity of PLCbeta3. PLCgamma is activated by both receptor and nonreceptor tyrosine kinases.PLCgamma forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLCgamma at Tyr771, 783 and 1245. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCgamma1. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Affinity purification | | Области исследований | Cancer,Cardiovascular,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts of Ramos cell line, using PLCG2 antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкл (100 мкг) | | Кат. номер: | CSB-PA018135KA01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Rabbit Anti Human PLCG2 PolyClonal Antibody.
Примечание: дополнительная информация (на английском языке). |
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