Rabbit Anti Human BUB1B PolyClonal Antibody

Спецификация

Объем	100 мкл (100 мкг)
Синонимы	Bub1b, BUB1beta, BUBR1, Bub1A, MAD3L, SSK1, hBUBR1
Клональность	Polyclonal Antibody
Организм	Human
uniprot	O60566
Иммуноген	Recombinant protein of human BUB1B
Источник	Rabbit
Видовая специфичность	Human, Mouse, Rat
Применение	ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200
Примечание	The Mitotic Checkpoint Complex (MCC), which contains Bub1, Bub1b, Bub3, Mad2, and Cdc20, controls chromosome segregation and monitors kinetochore-microtubule interactions. During mitosis, the MCC complex inhibits the ubiquitin ligase activity of the Anaphase Promoting Complex/Cyclosome (APC/C), thereby preventing cells with unaligned chromosomes from prematurely entering anaphase. Research studies have shown that Bub1b and Bub1 kinases are mutated in several types of human malignancies including hematopoietic, colorectal, lung, and breast cancers. Biallelic mutations in Bub1b have been found in mosaic variegated aneuploidy syndrome and premature chromatid separation syndrome. Bub1b mouse germline knockouts are embryonic lethal with heterozygous animals displaying genetic instability, early aging phenotypes, and increased cancer susceptibility. Bub3 binds both Bub1 and Bub1b, facilitating their recruitment to kinetochores, and is required for functional microtubule-kinetochore interactions.
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Non-conjugated
Буффер	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Форма	liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	Affinity purification
Области исследований	Epigenetics and Nuclear Signaling,Cancer,Cell biology
Ссылка на страницу на сайте производителя	ссылка
Western blot analysis of extracts of mouse testis tissue cell line, using BUB1B antibody.

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкл (100 мкг)
	Кат. номер:	CSB-PA002883KA01HU
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Rabbit Anti Human BUB1B PolyClonal Antibody. Примечание: дополнительная информация (на английском языке).