Rabbit Anti Human LYN PolyClonal Antibody

Спецификация

Объем	100 мкл (100 мкг)
Синонимы	LYN, FLJ26625, JTK8
Клональность	Polyclonal Antibody
Организм	Human
uniprot	P07948
Иммуноген	Recombinant protein of human LYN
Источник	Rabbit
Видовая специфичность	Human, Mouse, Rat
Применение	ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200
Примечание	Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivalent to Tyr416 of Src), located in the catalytic domain, correlates with enzyme activation. Csk-mediated phosphorylation of the carboxy-terminal Tyr507 (equivalent to Tyr527 of Src) inactivates the kinase. Tyrosine phosphorylation and activation of Lyn occurs upon association with cell surface receptors such as the B cell Ag receptor (BCR) and CD40. Studies using knockout mice have shown that the net effect of Lyn deficiency is to render B cells hypersensitive to BCR stimulation, suggesting that the most critical role for Lyn in vivo is in the down-regulation of B cell responses. Lyn is also involved in controlling the migration and development of specific B cell populations.
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Non-conjugated
Буффер	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Форма	liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	Affinity purification
Области исследований	Signal transduction
Ссылка на страницу на сайте производителя	ссылка
Western blot analysis of extracts of various cell lines, using LYN antibody.

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкл (100 мкг)
	Кат. номер:	CSB-PA013259KA01HU
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Rabbit Anti Human LYN PolyClonal Antibody. Примечание: дополнительная информация (на английском языке).