Rabbit Anti Human SNAI2 PolyClonal AntibodyСпецификация| Объем | 100 мкл (100 мкг) | | Синонимы | SNAI2,MGC10182,SLUG,SLUGH1,WS2D | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O43623 | | Иммуноген | Recombinant protein of human SNAI2 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200 | | Примечание | Slug (SNAI2) is a widely expressed transcriptional repressor and member of the Snail family of zinc finger transcription factors. Similar to the related Snail protein, Slug binds to the E-cadherin promoter region to repress transcription during development. The binding of Slug to integrin promoter sequences represses integrin expression and results in reduced cell adhesion. Down regulation of E-cadherin expression occurs during the epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells. The tumor suppressor protein p53 induces Slug expression in gamma-irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Deletion mutations in the corresponding Slug gene are associated with the pigmentation disorders Waardenburg Syndrome and Piebaldism, while a genetic duplication resulting in Slug overexpression is associated with a collection of congenital heart defects termed tetralogy of Fallot. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Affinity purification | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Developmental biology,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of pancreas cell lysate using SNAI2 antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкл (100 мкг) | | Кат. номер: | CSB-PA021869KA01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Rabbit Anti Human SNAI2 PolyClonal Antibody.
Примечание: дополнительная информация (на английском языке). |
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