Rabbit Anti Human DTNBP1 PolyClonal AntibodyСпецификацияОбъем | 100 мкл (100 мкг) | Синонимы | DTNBP1, DBND, DKFZp564K192, FLJ30031, HPS7, MGC20210, My031, SD | Клональность | Polyclonal Antibody | Организм | Human | uniprot | Q96EV8 | Иммуноген | Recombinant protein of human DTNBP1 | Источник | Rabbit | Видовая специфичность | Human, Mouse, Rat | Применение | ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200 | Примечание | Dysbindin, or dystrobrevin-binding protein 1, is a coiled-coil-containing protein expressed in muscle and brain that was identified as a binding partner of dystrobrevin. Dysbindin upregulates expression of the pre-synaptic proteins SNAP25 and synapsin I, thereby increasing glutamate release and promoting neuronal viability through Akt signaling. In particular, Akt phosphorylation is suppressed with downregulation of dysbindin and increased with upregulation of dysbindin. A nonsense mutation of dysbindin causes Hermansky-Pudlak disease, an autosomal recessive disorder characterized by lysosomal storage defects and prolonged bleeding. Genetic variation in the gene encoding dysbindin is strongly associated with schizophrenia and protein levels are reduced in the prefrontal cortex, midbrain and hippocampus of brains from patients with schizophrenia. | Клональность1 | Polyclonal | Изотип | IgG | Коньюгат | Non-conjugated | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | Форма | liquid | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | Метод очистки | Affinity purification | Области исследований | Neuroscience | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts of mouse brain cell lines, using DTNBP1 antibody.
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Информация для заказаОбласть использования: | Производство: | Cusabio | Метод: | | Объем: | 100 мкл (100 мкг) | Кат. номер: | CSB-PA007218KA01HU | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: Rabbit Anti Human DTNBP1 PolyClonal Antibody. Примечание: дополнительная информация (на английском языке). |
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