Rabbit Anti Human PTEN PolyClonal AntibodyСпецификацияОбъем | 100 мкл (100 мкг) | Синонимы | PTEN, BZS, DEC, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23del | Клональность | Polyclonal Antibody | Организм | Human | uniprot | P60484 | Иммуноген | Recombinant protein of human PTEN | Источник | Rabbit | Видовая специфичность | Human, Mouse, Rat | Применение | ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200 | Примечание | PTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers. PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase (PI3K). PTEN is a major negative regulator of the PI3K/Akt signaling pathway. PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity. PTEN regulates p53 protein levels and activityand is involved in G protein-coupled signaling during chemotaxis. | Клональность1 | Polyclonal | Изотип | IgG | Коньюгат | Non-conjugated | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | Форма | liquid | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | Метод очистки | Affinity purification | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Metabolism,Signal transduction | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts of HeLa cell lines, using PTEN antibody.
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Информация для заказаОбласть использования: | Производство: | Cusabio | Метод: | | Объем: | 100 мкл (100 мкг) | Кат. номер: | CSB-PA018964KA01HU | Цена (с НДС 20%): | по запросу | В корзину | Наименование: Rabbit Anti Human PTEN PolyClonal Antibody. Примечание: дополнительная информация (на английском языке). |
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