Rabbit Anti Human SMPD2 PolyClonal AntibodyСпецификация| Объем | 100 мкл (100 мкг) | | Синонимы | SMPD2,NSMASE,NSMASE1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O60906 | | Иммуноген | Recombinant protein of human SMPD2 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200 | | Примечание | Sphingomyelinases (SMases) catalyze the hydrolysis of sphingomyelin to produce ceramide and phosphocholine. Ceramide is an important bioactive lipid triggering signal transduction involved in cell proliferation, apoptosis and differentiation. A number of SMases have been described and categorized based on their optimum pH activity, cation dependence, tissue distribution, and subcellular localization. These include a lysosomal acid SMase, a Zn++-dependent secreted acid SMase, a membrane-bound Mg++-dependent neutral SMase, a Mg++-independent neutral SMase, and an alkaline SMase.nSMase1 (also termed SMPD2) is a Mg++-dependent neutral SMase that is widely expressed and predominantly localized to the endoplasmic reticulum. This protein has also been shown to have lyso-platelet activating factor (PAF) phospholipase C activity. A second neutral SMase, nSMase2 (also termed SMPD3) is predominantly expressed in the brain. The activity of neutral SMases is regulated by oxidative stress, chemotherapeutic drugs, inflammatory cytokines, and apoptotic stimuli. Analysis of single and double knockouts of the SMPD2 and SMPD3 has revealed that loss of both genes leads to complete loss of neutral SMase activity with developmental defects observed with loss of nSMase2. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Affinity purification | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of brian cell lysate using SMPD2 antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкл (100 мкг) | | Кат. номер: | CSB-PA021846KA01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Rabbit Anti Human SMPD2 PolyClonal Antibody.
Примечание: дополнительная информация (на английском языке). |
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