Rabbit Anti Human STUB1 PolyClonal AntibodyСпецификацияОбъем | 100 мкл (100 мкг) | Синонимы | STUB1,CHIP,HSPABP2,NY-CO-7,SDCCAG7,UBOX1 | Клональность | Polyclonal Antibody | Организм | Human | uniprot | Q9UNE7 | Иммуноген | Recombinant protein of human STUB1 | Источник | Rabbit | Видовая специфичность | Human, Mouse, Rat | Применение | ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200 | Примечание | The carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to the ubiquitin proteasome system. Cytoplasmic CHIP protein contains three 34-amino acid TPR (tetratricopeptide repeat) domains at its amino terminus and a carboxy-terminal U-box domain. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, while E3 ubiquitin ligase activity is confined to the U-box domain. The binding of CHIP to Hsp70 can stall the folding of Hsp70 client proteins and concomitantly facilitate the U-box dependent ubiquitination of Hsp70-bound substrates. CHIP appears to play a central role in cell stress protection and is responsible for the degradation of disease-related proteins that include cystic fibrosis transmembrane conductance regulator, p53, huntingtin and Ataxin-3, Tau protein, and alpha-synuclein. | Клональность1 | Polyclonal | Изотип | IgG | Коньюгат | Non-conjugated | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | Форма | liquid | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | Метод очистки | Affinity purification | Области исследований | Epigenetics and Nuclear Signaling,Signal transduction | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts of various cell lines, using STUB1 antibody.
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Информация для заказаОбласть использования: | Производство: | Cusabio | Метод: | | Объем: | 100 мкл (100 мкг) | Кат. номер: | CSB-PA022887KA01HU | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: Rabbit Anti Human STUB1 PolyClonal Antibody. Примечание: дополнительная информация (на английском языке). |
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