Rabbit Anti Human DPYD PolyClonal Antibody

Спецификация

Объем	100 мкл (100 мкг)
Синонимы	DPYD, DHP, DPD, DHPDHASE
Клональность	Polyclonal Antibody
Организм	Human
uniprot	Q12882
Иммуноген	Recombinant protein of human DPYD
Источник	Rabbit
Видовая специфичность	Human, Mouse, Rat
Применение	ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200
Примечание	Dihydropyrimidine dehydrogenase (DPD, DPYD) catalyzes the initial and rate-limiting step in uracil and thymidine catabolism as well as catabolism of the chemotherapeutic drug 5-fluorouracil (5-FU) and its derivatives. DPYD deficiency, which results from mutations in the DPYD gene, causes errors in pyrimidine metabolism and potentially life-threatening side effects in cancer patients treated with 5-FU (reviewed in 1). As a result, ongoing work examines whether or how DPYD gene variation and protein expression can be used to predict 5-FU toxicity. Several genes that impart resistance to 5-FU were recently identified in human hepatocellular carcinoma (HCC). AEG-1, which is highly expressed in HCC, increases the expression of DPYD. DPYD is expressed more highly in HCC than in normal liver, and this is thought to be one mechanism of 5-FU resistance.
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Non-conjugated
Буффер	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Форма	liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	Affinity purification
Области исследований	Cancer,Metabolism,Signal transduction
Ссылка на страницу на сайте производителя	ссылка
Western blot analysis of extracts of various cell lines, using DPYD antibody.

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкл (100 мкг)
	Кат. номер:	CSB-PA007168KA01HU
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Rabbit Anti Human DPYD PolyClonal Antibody. Примечание: дополнительная информация (на английском языке).