Rabbit Anti Human PTPN6 PolyClonal Antibody

Спецификация

Объем	100 мкл (100 мкг)
Синонимы	PTPN6,HCP,HCPH,HPTP1C,PTP-1C,SH-PTP1,SHP-1,SHP-1L,SHP1,SH-PTP1
Клональность	Polyclonal Antibody
Организм	Human
uniprot	P29350
Иммуноген	Recombinant protein of human PTPN6
Источник	Rabbit
Видовая специфичность	Human, Mouse, Rat
Применение	ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200
Примечание	SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation. Because SHP-1 downregulates various proliferation pathways, SHP-1 is considered a potential tumor suppressor and angiogenesis regulator.
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Non-conjugated
Буффер	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Форма	liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	Affinity purification
Области исследований	Cancer,Cell biology,Developmental biology,Signal transduction
Ссылка на страницу на сайте производителя	ссылка
Western blot analysis of extracts of various cell lines, using PTPN6 antibody.

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:
	Объем:	100 мкл (100 мкг)
	Кат. номер:	CSB-PA019043KA01HU
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Rabbit Anti Human PTPN6 PolyClonal Antibody. Примечание: дополнительная информация (на английском языке).