ABCB4 Antibody, Biotin conjugatedСпецификация| Объем | 50 мкг | | Синонимы | Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (EC 3.6.3.44) (P-glycoprotein 3), ABCB4, MDR3 PGY3 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P21439 | | Иммуноген | Recombinant Human Phosphatidylcholine translocator ABCB4 protein (530-693AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Biotin | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Phosphatidylcholine translocator ABCB4 | | Области исследований | Cancer, Metabolism, Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 50 мкг | | Кат. номер: | CSB-PA001050LD01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: ABCB4 Antibody, Biotin conjugated.
Примечание: дополнительная информация (на английском языке). |
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