AKAP10 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | A kinase anchor protein 10, mitochondrial [Precursor], Protein kinase A-anchoring protein 10, PRKA10, Dual specificity A kinase-anchoring protein 2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O43572 | | Иммуноген | Synthesized peptide derived from Internal of human AKAP10. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase By similarity.<br/><br/>Wang L., Proc. Natl. Acad. Sci. U.S.A. 98:3220-3225(2001).<br/>Chatterjee T.K., Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from mouse brain cells, using AKAP10 antibody.
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Наименование: AKAP10 Antibody.