AKT1/AKT2/AKT3 (Ab-315/316/312) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | RAC-PK-alpha, Protein kinase B, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P31749/P31751/Q9Y243 | | Иммуноген | Peptide sequence around aa.313~317/314~318/310~314 (P-E-Y-L-A) derived from Human AKT1/AKT2/AKT3. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, IHC,IHC:1:50-1:100 | | Примечание | General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. /IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.<br/><br/>Nelms K, et al. (1999) Annu Rev Immunol. 17:701-738.<br/>Malabarba M G, et al. (1996) Biochem. J. 319:865-872.<br/>Hou J, et al. (1994) Science. 265:1701-1706.<br/>Quelle F W, et al. (1995) Mol Cell Biol. 15: 3336-3343.<br/>Takeda K, et al. (1996) Nature. 380: 627-630.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using AKT1/AKT2/AKT3(Ab-315/316/312) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA054234 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: AKT1/AKT2/AKT3 (Ab-315/316/312) Antibody.
Примечание: дополнительная информация (на английском языке). |
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