APAF1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | APAF1-interacting protein, APIP, APIP2, CGI-29 protein, MMRP19 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O14727 | | Иммуноген | Synthesized peptide derived from human APAF-1-ALT. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:200, IF:1:100-1:200 | | Примечание | This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.<br/><br/>Keigo Machida, J. Biol. Chem., Apr 2001, 276: 12140 - 12146.<br/>Liam O 鐤宱nnor, Cancer Res., Mar 2000, 60: 1217 - 1220.<br/>Zeping Wang, Nucleic Acids Res., Apr 2005, 33: 2248 - 2258<br/>Govindaraj Anumanthan, Cancer Res., Nov 2006, 66: 10824 - 10832. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Cell biology,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COLO205, using APAF-1-ALT antibody.
 | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using APAF-1-ALT antibody.
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Наименование: APAF1 Antibody.