APP (Ab-668) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | AAA, AD1, PN2, ABPP, APPI | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P05067 | | Иммуноген | Peptide sequence around aa.666~670 (A-V-T-P-E ) derived from Human APP. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:1000, IF:1:100-1:200 | | Примечание | APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.<br/><br/>Hung, A.Y. and Selkoe, D.J. (1994) EMBO J. 13, 534-542.<br/>Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122<br/>Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427.<br/>Iijima, K.I. et al. (2000) J. Neurochem. 75, 1085-1091<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from mouse brain tissue using APP(Ab-668) Antibody and the same antibody preincubated with blocking peptide.
 | Immunofluorescence staining of methanol-fixed MCF cells using APP(Ab-668) Antibody.
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Наименование: APP (Ab-668) Antibody.