Объем | 100 мкл |
Синонимы | Cyclic AMP-dependent transcription factor ATF-3, Activating transcription factor 3, ATF3, |
Клональность | Polyclonal Antibody |
Организм | Human |
uniprot | P18847 |
Иммуноген | Synthesized peptide derived from internal of human ATF3. |
Источник | Rabbit |
Видовая специфичность | Human, Mouse, Rat |
Применение | ELISA, WB,WB:1:500-1:3000 |
Примечание | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.<br/><br/>Chen B.P.C., J. Biol. Chem. 269:15819-15826(1994).<br/>Hai T., Genes Dev. 3:2083-2090(1989).<br/>Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004). |
Клональность1 | Polyclonal |
Изотип | IgG |
Коньюгат | Non-conjugated |
Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Форма | liquid |
Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Области исследований | Epigenetics and Nuclear Signaling,Cancer |
Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from RAW264.7 cells, using ATF3 antibody.
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