| Объем | 100 мкл |
| Синонимы | APG4 autophagy 4 homolog C, APG4-C, APG4C, AUT-like 3 cysteine endopeptidase, AUTL1 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q96DT6 |
| Иммуноген | Synthesized peptide derived from internal of human ATG4C. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Примечание | Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation By similarity. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.<br/><br/>Marino G., J. Biol. Chem. 278:3671-3678(2003).<br/>Chen J.M., Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.<br/>Ota T., Nat. Genet. 36:40-45(2004).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Cancer,Cardiovascular,Cell biology,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from K562 cells and COS7 cells, using ATG4C antibody.
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Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using ATG4C antibody.
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Immunofluorescence analysis of HuvEc cells, using ATG4C antibody.
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Наименование: ATG4C Antibody.