ATR (Ab-428) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FRP1, MEC1, SCKL, SCKL1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q13535 | | Иммуноген | Peptide sequence around aa.426~430 (G-I-S-P-K) derived from Human ATR. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, IHC,IHC:1:50-1:100 | | Примечание | ATR encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.<br/><br/>Zhou, X.Z. et al. (1999) Cell Mol. Life Sci. 56, 788-806.<br/>Pinna, L.A. and Ruzzene, M. (1996) Biochim. Biophys. Acta 1314, 191-225.<br/>Kastan, M.B. and Lim, D.S. (2000) Nat. Rev. Mol. Cell Biol. 1, 179-186.<br/>Shechter, D. et al. (2004) DNA Repair (Amst) 3, 901-908.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATR(Ab-428) Antiobdy(left) or the same antibody preincubated with blocking peptide(right).
 | | | |
Информация для заказа |
Наименование: ATR (Ab-428) Antibody.