| Объем | 100 мкл |
| Синонимы | Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A), ATF7, ATFA |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P17544 |
| Иммуноген | Recombinant Human Cyclic AMP-dependent transcription factor ATF-7 protein (1-117AA) |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC, Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 |
| Примечание | Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen Affinity Purified |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot
All lanes: ATF7 antibody at 12µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 53, 50, 51, 34, 14, 52 kDa
Observed band size: 53 kDa
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Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA002279ESR1HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA002279ESR1HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA002279ESR1HU at dilution of 1:100
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Наименование: ATF7 Antibody.