AXIN2 AntibodyСпецификация| Объем | 50 мкл | | Синонимы | axin 2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9Y2T1 | | Иммуноген | Fusion protein of human AXIN2 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 | | Примечание | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Cell biology,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | The image is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA577711(AXIN2 Antibody) at dilution 1/20. (Original magnification: ?200)
 | The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA577711(AXIN2 Antibody) at dilution 1/20. (Original magnification: ?200)
 | Gel: 6%SDS-PAGE, Lysate: 40 ?g, Lane: Mouse brain tissue, Primary antibody: CSB-PA577711(AXIN2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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Наименование: AXIN2 Antibody.