CABLES2 AntibodyСпецификация| Объем | 50 мкл | | Синонимы | Cdk5 and Abl enzyme substrate 2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9BTV7 | | Иммуноген | Synthetic peptide of human CABLES2 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, IHC,ELISA:1:1000-1:2000, IHC:1:25-1:100 | | Примечание | Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Cancer,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA086010(CABLES2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ?200)
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA086010(CABLES2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ?200)
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Наименование: CABLES2 Antibody.