| Объем | 100 мкл |
| Синонимы | BCL2 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P10415 |
| Иммуноген | Peptide sequence around aa.68~72 (R-T-S-P-L) derived from Human BCL-2. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 |
| Примечание | BCL-2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.<br/><br/>Muller IM, et al. (2005) Mol Pharmacol.<br/>Jin Z, Gao F,et al. J Biol Chem 2004 Sep 17, 279(38): 40209-19.<br/>Kumar Biswas S,et al. Mol Cancer Ther 2004 Mar, 3(3): 327-34.<br/>Huang ST,et al. (2002)FASEB J, 16(8): 825-32.<br/>Yamamoto K,et al. (1999) Mol Cell Biol, 19(12): 8469-78.<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Области исследований | Cancer,Cell biology,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from MCF cells using BCL-2(Ab-70) Antibody and the same antibody preincubated with blocking peptide.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BCL-2(Ab-70) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Immunofluorescence staining of methanol-fixed Hela cells using BCL-2(Ab-70) Antibody.
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Наименование: BCL2 (Ab-70) Antibody.