| Объем | 100 мкл |
| Синонимы | Apoptosis regulator Bcl-X |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q07817 |
| Иммуноген | Peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL . |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.<br/><br/>Basu A, et.al.( 2003) Mar 13, 538(1-3): 41-7<br/>Cheng E.H.-Y. et.al. (1996) Nature 379:554-556.<br/>Sattler M. et.al. (1997), Science 275:983-986.<br/>Muchmore S.W.et.al (1996).Nature 381:335-341<br/>Yu J., Zhang L. Mol. (2001)Cell 7:673-682<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Области исследований | Cancer,Cell biology,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 293 and Hela cells using BCL-XL(Ab-62) antibody.
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Наименование: BCL2L1 (Ab-62) Antibody.