| Объем | 100 мкл |
| Синонимы | BCL-6 corepressor, BCoR, BCOR, KIAA1575, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q6W2J9 |
| Иммуноген | Synthesized peptide derived from internal of human BCOR. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A, impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells, the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).<br/><br/>Huynh K.D., Genes Dev. 14:1810-1823(2000).<br/>Ng D., Nat. Genet. 36:411-416(2004).<br/>Nagase T., DNA Res. 7:273-281(2000).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from COLO cells, using BCOR antibody.
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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using BCOR antibody.
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Наименование: BCOR Antibody.