CALR AntibodyСпецификация| Объем | 50 мкл | | Синонимы | Calreticulin | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P27797 | | Иммуноген | Fusion protein of human CALR | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 | | Примечание | Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Tags & Cell Markers | | Ссылка на страницу на сайте производителя | ссылка | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA963019(CALR Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ?200)
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA963019(CALR Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ?200)
 | Gel: 10%SDS-PAGE, Lysate: 40 ?g, Lane 1-3: Hela cells, 293T cells, NIH/3T3 cells, Primary antibody: CSB-PA963019(CALR Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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Наименование: CALR Antibody.