CBL (Ab-700) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Signal transduction protein CBL, Proto-oncogene c-CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P22681 | | Иммуноген | Peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.<br/><br/>Blake, T.J. et al. (1991) Oncogene 6, 653-657.<br/>Thien, C.B. and Langdon, W.Y. (1998) Immunol. Cell Biol. 76, 473-482.<br/>Kamei, T. et al. (2000) Int. J. Oncol. 17, 335-339.<br/>Hunter, C. et al. (1999) J. Biol. Chem. 274, 2097-2106.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela and HT29 cells using c-Cbl(Ab-700) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using c-Cbl(Ab-700) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: CBL (Ab-700) Antibody.