CEP131 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | 5-azacytidine-induced 1, centrosomal protein of 131 kDa, Cep131, pre-acrosome localization 1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9UPN4 | | Иммуноген | Synthesized peptide derived from internal of human AZI1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Component of centriolar satellites, which build a complex and dynamic network required to regulate cilia/flagellum formation. During normal and stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a p38 MAPK-dependent manner. In contrast, in proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. Acts also as a negative regulator for the trafficking from the centriolar satellite BBSome protein complex to the cilia. Plays a role in sperm flagellar formation, may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression, may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells.<br/><br/>Kikuno R., DNA Res. 6:197-205(1999).<br/>Andersen J.S., Nature 426:570-574(2003).<br/>Olsen J.V., Cell 127:635-648(2006). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Tags & Cell Markers | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HUVEC cells, using AZI1 antibody.
 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using AZI1 antibody.
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Наименование: CEP131 Antibody.