CMKLR1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Chemokine receptor-like 1, G-protein coupled receptor DEZ, G-protein coupled receptor ChemR23, CHEMR23, DEZ | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q99788 | | Иммуноген | Synthesized peptide derived from internal of human CMKLR1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).<br/><br/>Methner A., Biochem. Biophys. Res. Commun. 233:336-342(1997).<br/>Samson M., Eur. J. Immunol. 28:1689-1700(1998).<br/>Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cell biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2 cells, HeLa cells and 293 cells, using CMKLR1 antibody.
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Наименование: CMKLR1 Antibody.