COL4A1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | COL4A1 NC1 domain, COLLAGEN OF BASEMENT MEMBRANE, ALPHA-1 CHAIN ARRESTEN, alpha 1 type IV collagen preproprotein, collagen IV alpha-1 polypeptide | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P02462 | | Иммуноген | Synthesized peptide derived from human Collagen IV. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.<br/><br/>Mary K. Chelberg, Cancer Res., Sep 1989, 49: 4796 - 4802.<br/>Patricia L. Graham, J. Cell Biol., Jun 1997, 137: 1171.<br/>PJ Lein, J. Cell Biol., Apr 1991, 113: 417.<br/>EC Tsilibary, J. Biol. Chem., Dec 1988, 263: 19112 - 19118.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Others | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa cells, using Collagen IV antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Collagen IV antibody.
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Наименование: COL4A1 Antibody.