COPS3 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | SGN3, COP9, SUBUNIT 3, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9UNS2 | | Иммуноген | Synthesized peptide derived from human JAB1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 | | Примечание | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.<br/><br/>George Z. Rassidakis, Clin. Cancer Res., Mar 2003, 9: 1121.<br/>Ricardo V. Lloyd, Am. J. Pathol., Mar 2002, 160: 1171.<br/>Shu Xiao, PNAS, Oct 2006, 103: 16448 - 16453.<br/>Alex Kudrin, J. Biol. Chem., Oct 2006, 281: 29641 - 29651.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Neuroscience,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Immunofluorescence analysis of HeLa cells, treated with Forskolin (40nM, 30mins), using JAB1 antibody.
 | Western blot analysis of extracts from LOVO cells, using JAB1 antibody.
 | Western blot analysis of extracts from A549 cells (Lane 2) and HepG2 cells (Lane 3), using JAB1 antiobdy. The lane on the left is treated with systhesized peptide.
 | | | |
Информация для заказа |
Наименование: COPS3 Antibody.