| Объем | 50 мкг |
| Синонимы | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8), COPS8, CSN8 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q99627 |
| Иммуноген | Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA) |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, IHC, Recommended dilution: IHC:1:200-1:500 |
| Примечание | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Абревеатура | COP9 signalosome complex subunit 8 |
| Области исследований | Cell biology, Developmental biology, Immunology, Signal transduction, Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
IHC image of CSB-PA860346LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system.
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Наименование: COPS8 Antibody.