| Объем | 50 мкл |
| Синонимы | COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q12887 |
| Иммуноген | Fusion protein of human COX10 |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, IHC,ELISA:1:500-1:2000, IHC:1:50-1:200 |
| Примечание | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen affinity purification |
| Области исследований | Tags & Cell Markers,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
The image is immunohistochemistry of paraffin-embedded Human renal cancer tissue using CSB-PA257877(COX10 Antibody) at dilution 1/100. (Original magnification: 200)
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Наименование: COX10 Antibody.